Antigen presentation by intestinal epithelial cells.
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منابع مشابه
Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.
The high concentration of foreign antigen in the lumen of the gastrointestinal tract is separated from the underlying lymphocytes by a single cell layer of polarized epithelium. Intestinal epithelial cells can express HLA class II antigens and may function as antigen-presenting cells to CD4(+) T cells within the intestinal mucosa. Using tetanus toxoid specific and HLA-DR-restricted T lymphocyte...
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Van Niel, Guillaume, and Martine Heyman. The Epithelial Cell Cytoskeleton and Intracellular Trafficking. II. Intestinal epithelial cell exosomes: perspectives on their structure and function. Am J Physiol Gastrointest Liver Physiol 283: G251–G255, 2002; 10.1152/ajpgi.00102.2002.— Intestinal epithelial cells (IEC) are located at the strategic interface between the external environment and the mo...
متن کاملIntestinal epithelial cells use two distinct pathways for HLA class II antigen processing.
Intestinal epithelial cells express a low level of HLA class II molecules constitutively, with elevated levels seen in the setting of mucosal inflammation including inflammatory bowel disease. The ability of intestinal epithelial cells to act as antigen presenting cells for alphabeta CD4(+) T lymphocytes was examined through a molecular analysis of the HLA class II antigen processing pathway. W...
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Mayer, Lloyd. Current Concepts in Mucosal Immunity. I. Antigen presentation in the intestine: new rules and regulations. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G7–G9, 1998.—The recognition that immune responses in the intestine differ from those seen systemically has led to a search for novel pathways involved in mucosal immunoregulation. One cell type that has surfaced as a pri...
متن کاملSalidroside regulates the expressions of IL-6 and defensins in LPS-activated intestinal epithelial cells through NF-κB/MAPK and STAT3 pathways
Objective(s): To reveal the detailed mechanism underlying the functions of salidroside on the inflammation of intestinal epithelial cells during IBD.Materials and Methods: Quantitative real-time PCR was employed to assess the expression of IL-6, IL-10, and α-defensins 5 and 6. ELISA assay was performed to measure the secretion of IL-6 and IL-10. MTT assay was used to determine the cell viabilit...
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عنوان ژورنال:
- Immunology letters
دوره 69 1 شماره
صفحات -
تاریخ انتشار 1993